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KMID : 0861020090240040069
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Korea Journal of Herbology
2009 Volume.24 No. 4 p.69 ~ p.75
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Effects of Black Ginseng on Hypertension-induced Rats
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Song Nak-Kun
Choi Hak-Joo
Kim Dong-Hee
Roh Seong-Soo
Seo Young-Bae
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Abstract
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Objectives: To access the safety and efficacy of Black Ginseng (BG), a traditional herbal medicine on hypertension, we examined various parameters involved in the pathogenesis of hypertension.
Methods: We made deoxycorticosterone acetate (DOCA;25 mg/kg/3times/weeks for 3 weeks)- induced hypertension Sprague-Dawley (SD) rats. And experiment group was treated with extract of black ginseng (BG;200 mg/kg/day).
Results: In results, the weight of experiment group treated with BG was increased compared with normal and control group. And the heart and lung weights of experiment group were decreased compared with control group. The blood pressure and pulse rate of group treated with BG were significantly decreased compared with control group. In addition, BG greatly reduced the levels of aldosterone. These results suggested that BG has suppressive effects on hypertension, and BG has potential as a safe and effective therapeutics for hypertension.
Conclusions: The present data show evidences on anti-hypertension activity of BG in an experimental animal system, which can provide further insights into the development of anti-hypertension therapeutic agents.
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KEYWORD
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Black ginseng, hypertension, DOCA salt
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